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Article

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3.

Nature genetics - 1 Jul 1997

Chesi M, Nardini E, Brents L A, Schröck E, Ried T, Kuehl W M, Bergsagel P L

Abstract excerpt

Dysregulation of oncogenes by translocation to the IgH locus (14q32) is a seminal event in the pathogenesis of B-cell tumours. In multiple myeloma (MM), translocations to the IgH locus have been reported at an incidence of 20-60%. For most translocations, the partner chromosome is unknown (14q+);...

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Identifiers

PMID: 9207791
DOI: 10.1038/ng0797-260
PMCID: PMC3901950

Genes

FGFR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9207791-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3.PMID 9207791Read ↗

A Novel Chromosomal Translocation t(4; 14)(p16.3; q32) in Multiple Myeloma Involves the Fibroblast Growth-Factor Receptor 3 GeneSemantic proximity Read ↗

Frequent Dysregulation of the c-maf Proto-Oncogene at 16q23 by Translocation to an Ig Locus in Multiple MyelomaSemantic proximity Read ↗

Frequent Dysregulation of the c-maf Proto-Oncogene at 16q23 by Translocation to an Ig Locus in Multiple MyelomaSemantic proximity Read ↗

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Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myelomaSemantic proximity Read ↗

High incidence of cryptic translocations involving the Ig heavy chain gene in multiple myeloma, as shown by fluorescence in situ hybridizationSemantic proximity Read ↗

The recurrent translocation t(14;20)(q32;q12) in multiple myeloma results in aberrant expression of <i>MAFB</i>: a molecular and genetic analysis of the chromosomal breakpointSemantic proximity Read ↗

In multiple myeloma, 14q32 translocations are nonrandom chromosomal fusions driving high expression levels of the respective partner genesSemantic proximity Read ↗

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The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3and a Novel Gene, MMSET, Resulting in IgH/MMSET Hybrid TranscriptsSemantic proximity Read ↗

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