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Article

Imaging flow cytometry-based multiplex FISH for three IGH translocations in multiple myeloma

8 Mar 2023

Abstract excerpt

Abstract Three types of chromosomal translocations, t(4;14)(p16;q32), t(14;16)(q32;q23), and t(11;14)(q13;q32), are associated with prognosis and the decision making of therapeutic strategy for multiple myeloma (MM). In this study, we developed a new diagnostic modality of the multiplex FISH in immunophenotyped cells in suspension (Immunophenotyped-Suspension-Multiplex (ISM)-FISH). For the ISM-FISH, we first...

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PMID: 36882509
DOI: 10.1038/s10038-023-01136-2

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