Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A potential role for centrosomal deregulation within IgH translocation-positive myeloma.

Medical hypotheses - 1 Jan 2005

Maxwell Christopher A, Pilarski Linda M

Abstract excerpt

Multiple myeloma is a late stage B-cell malignancy that is characterized by recurrent translocations into the immunoglobulin heavy chain locus as well as multiple and complex chromosomal abnormalities. Multiple myeloma is not characterized by a defining IgH translocation partner locus; rather, the frequency of individual translocations ranges from 5% to 15% of the patient population. The current hypothesis that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Centrosome
Share to Cyclin D
Share to Cyclins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Immunoglobulin Heavy Chains

Share to Models, Biological

Share to Multiple Myeloma

Share to Translocation, Genetic

Source

Identifiers

PMID: 16023302
DOI: 10.1016/j.mehy.2005.05.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A potential role for centrosomal deregulation within IgH translocation-positive myeloma.PMID 16023302Read ↗

Chromosome translocations in multiple myeloma.Semantic proximity Read ↗

Advances in biology of multiple myeloma: clinical applicationsSemantic proximity Read ↗

Molecular pathogenesis and a consequent classification of multiple myeloma.Semantic proximity Read ↗

Multiple myeloma immunoglobulin lambda translocations portend poor prognosisSemantic proximity Read ↗

Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma.Semantic proximity Read ↗

Genetic and molecular mechanisms in multiple myeloma: a route to better understand disease pathogenesis and heterogeneitySemantic proximity Read ↗

Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myelomaSemantic proximity Read ↗

Mechanisms and Clinical Applications of Genome Instability in Multiple Myeloma.Semantic proximity Read ↗

Genome instability in multiple myeloma.Semantic proximity Read ↗

Chromosomal instability and acquired drug resistance in multiple myelomaSemantic proximity Read ↗

The Genetic Architecture of Multiple MyelomaSemantic proximity Read ↗

Cell autonomous and microenvironmental regulation of tumor progression in precursor states of multiple myeloma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.