Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with changes in transcriptional profiles.

doi:10.1002/ajh.23339

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Article

Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with changes in transcriptional profiles.

American journal of hematology - 1 Jan 2013

Mosca Laura, Musto Pellegrino, Todoerti Katia, Barbieri Marzia, Agnelli Luca, Fabris Sonia, Tuana Giacomo, Lionetti Marta, Bonaparte Eleonora, Sirchia Silvia Maria, Grieco Vitina, Bianchino Gabriella, D'Auria Fiorella, Statuto Teodora, Mazzoccoli Carmela, De Luca Luciana, Petrucci Maria Teresa, Morabito Fortunato, Offidani Massimo, Di Raimondo Francesco, Falcone Antonietta, Caravita Tommaso, Omedè Paola, Boccadoro Mario, Palumbo Antonio, Neri Antonino

Abstract excerpt

Primary plasma cell leukemia (pPCL) is a rare, yet aggressive form of de novo plasma cell tumor, distinct from secondary PCL (sPCL) which represents a leukemic transformation of pre-existing multiple myeloma (MM). Herein, we performed a comprehensive molecular analysis of a prospective series of pPCLs by means of FISH, single nucleotide polymorphism (SNP) array and gene expression profiling (GEP). IGH@...

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PMID: 23044976
DOI: 10.1002/ajh.23339

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