Article
Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant with opiate addiction in Hispanic women.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2008
Oosterhuis Bronson E, LaForge K Steven, Proudnikov Dmitri, Ho Ann, Nielsen David A, Gianotti Robert, Barral Sandra, Gordon Derek, Leal Suzanne M, Ott Jurg, Kreek Mary Jeanne
Abstract excerpt
Catechol-O-methyltransferase (COMT) catalyzes the breakdown of catechol neurotransmitters, including dopamine, which plays a prominent role in drug reward. A common single nucleotide polymorphism (SNP), G472A, codes for a Val158Met substitution and results in a fourfold down regulation of enzyme activity. We sequenced exon IV of COMT gene in search for novel polymorphisms and then genotyped four out of five...
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