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Article

Comprehensive assessment of genetic variation of catechol-O-methyltransferase and breast cancer risk.

Cancer research - 1 Oct 2006

Gaudet Mia M, Chanock Stephen, Lissowska Jolanta, Berndt Sonja I, Peplonska Beata, Brinton Louise A, Welch Robert, Yeager Meredith, Bardin-Mikolajczak Alicja, Garcia-Closas Montserrat

Abstract excerpt

Because catechol-O-methyltransferase (COMT) catalyzes the addition of methyl groups to stabilize catechol estrogens that may induce DNA damage, genetic variants could influence breast cancer risk. To comprehensively characterize genetic variation in this gene, we selected haplotype-tagging single nucleotide polymorphisms (htSNP) in COMT. A total of 11 htSNPs (including COMT Val(158)Met) were selected based on the...

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Identifiers

PMID: 17018638
DOI: 10.1158/0008-5472.CAN-06-1294

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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