Article
Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York.
Breast cancer research and treatment - 1 Sept 2006
Gaudet Mia M, Bensen Jeannette T, Schroeder Jane, Olshan Andrew F, Terry Mary Beth, Eng Sybil M, Teitelbaum Susan L, Britton Julie A, Lehman Teresa A, Neugut Alfred I, Ambrosone Christine B, Santella Regina M, Gammon Marilie D
Abstract excerpt
The gene encoding catechol-O-methyltransferase (COMT), critical to the inactivation of reactive catechol estrogens, has several single nucleotide polymorphisms (SNPs) that influence enzyme activity. A 3-SNP haplotype (IVS1+255 C>T; Ex4-12 G>A; 3'UTR-521 A>G), which has been shown to reduce COMT expression in the human brain, has been identified. To evaluate the influence of genetic variation of COMT on breast...
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