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Article

Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome.

Molecular and cellular endocrinology - 5 Mar 2012

Hill Lori D, Ewens Kathryn G, Maher Brion S, York Timothy P, Legro Richard S, Dunaif Andrea, Strauss Jerome F

Abstract excerpt

Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects 5-8% of reproductive age women. The primary features of PCOS are hyperandrogenemia, chronic anovulation and infertility. It has been suggested that defects in ovarian steroid metabolism contribute to the follicular growth arrest and abnormal production of ovarian steroid hormones that are characteristic of PCOS. 2-Methoxyestradiol (2-ME) is...

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Source

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Identifiers

PMID: 22178088
DOI: 10.1016/j.mce.2011.11.022
PMCID: PMC3264817

Genes

COMT
SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome.PMID 22178088Read ↗

Comprehensive assessment of genetic variation of catechol-O-methyltransferase and breast cancer risk.Semantic proximity Read ↗

Association of COMT haplotypes and breast cancer risk in caucasian women.Semantic proximity Read ↗

A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).Semantic proximity Read ↗

Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk: evidence from a meta-analysis of 3,940 individuals.Semantic proximity Read ↗

The catechol-O-methyltransferase gene: its regulation and polymorphisms.Semantic proximity Read ↗

Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.Semantic proximity Read ↗

Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.Semantic proximity Read ↗

Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial.Semantic proximity Read ↗

Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer.Semantic proximity Read ↗

Importance of the COMT gene for sex differences in brain function and predisposition to psychiatric disorders.Semantic proximity Read ↗

Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulatorSemantic proximity Read ↗

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