Article
Single nucleotide polymorphism discovery and haplotype analysis of Ca2+-dependent K+ channel beta-1 subunit.
Pharmacogenetics and genomics - 1 Apr 2007
Gong Yan, Beitelshees Amber L, Wessel Jennifer, Langaee Taimour Y, Schork Nicholas J, Johnson Julie A
Abstract excerpt
The large-conductance, Ca-dependent K channel plays a key role in the control of vascular tone. Variation in the gene encoding the beta-1 subunit of the Ca-dependent K channel (KCNMB1) has been reported to be associated with hypertension, however, variants in KCNMB1 have not been systematically characterized to date. In this study, we have performed the most comprehensive evaluation to date of single nucleotide...
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