Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction.

Journal of hypertension - 1 Nov 2008

Tomás Marta, Vázquez Esther, Fernández-Fernández José M, Subirana Isaac, Plata Cristina, Heras Magda, Vila Joan, Marrugat Jaume, Valverde Miguel A, Sentí Mariano

Abstract excerpt

OBJECTIVE: The large conductance Ca2+ -dependent potassium channel plays a critical role in the control of vascular tone, coupling local increases in intracellular Ca2+ to membrane hyperpolarization and vascular relaxation. It also impacts blood pressure by modulating the renin-angiotensin-aldosterone system. Previous studies have shown that a polymorphism in the beta1 regulatory subunit of the Ca2+ -dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Large-Conductance Calcium-Activated Potassium Channel alpha Subunits

Share to Myocardial Infarction

Share to Polymorphism, Single Nucleotide

Share to Population Surveillance

Share to Risk Factors

Source

Identifiers

PMID: 18854754
DOI: 10.1097/HJH.0b013e32831103d8

Genes

KCNMA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction.PMID 18854754Read ↗

Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease.Semantic proximity Read ↗

Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension.Semantic proximity Read ↗

The KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in the Inter99 study of 5729 Danes.Semantic proximity Read ↗

Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population.Semantic proximity Read ↗

Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factorsSemantic proximity Read ↗

Single nucleotide polymorphism discovery and haplotype analysis of Ca2+-dependent K+ channel beta-1 subunit.Semantic proximity Read ↗

Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk.Semantic proximity Read ↗

H558R, a common SCN5A polymorphism, modifies the clinical phenotype of Brugada syndrome by modulating DNA methylation of SCN5A promoters.Semantic proximity Read ↗

A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction.Semantic proximity Read ↗

CaMK4 Gene Deletion Induces HypertensionSemantic proximity Read ↗

Association of alpha-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population.Semantic proximity Read ↗

High prevalence of Arginine to Glutamine substitution at 98, 141 and 162 positions in Troponin I (TNNI3) associated with hypertrophic cardiomyopathy among Indians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.