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Article

Functional BSND variants in essential hypertension.

American journal of hypertension - 1 Nov 2007

Sile Saba, Gillani Niloufar B, Velez Digna R, Vanoye Carlos G, Yu Chang, Byrne Loretta M, Gainer James V, Brown Nancy J, Williams Scott M, George Alfred L

Abstract excerpt

BACKGROUND: Defects in the handling of renal salt reabsorption may contribute to interindividual differences in blood-pressure regulation and susceptibility to hypertension. Sodium chloride reabsorption in the thick ascending limb (TAL) is dependent in part on the chloride channel, ClC-Kb (encoded by CLCNKB), and its accessory subunit, barttin (encoded by BSND). METHODS: We investigated genetic variations in BSND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17954364
DOI: 10.1016/j.amjhyper.2007.07.003

Genes

BSND
CLCNKB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional BSND variants in essential hypertension.PMID 17954364Read ↗

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Activating mutation of the renal epithelial chloride channel ClC-Kb predisposing to hypertension.Semantic proximity Read ↗

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Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III.Semantic proximity Read ↗

ClC-Kb pore mutation disrupts glycosylation and triggers distal tubular remodeling.Semantic proximity Read ↗

Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension.Semantic proximity Read ↗

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