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Article

Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease.

Pflugers Archiv : European journal of physiology - 1 Jul 2010

Köhler Ralf

Abstract excerpt

In the cardiovascular system, Ca2+-activated K+-channels (KCa) are considered crucial mediators in the control of vascular tone and blood pressure by modulating the membrane potential and shaping Ca2+-dependent contraction. Vascular smooth muscle cells express the BKCa channel which fine-tunes contractility by providing a negative feedback on Ca2+-elevations. BKCa channel's ion-conducting alpha-subunit is encoded...

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Share to Cardiac electrophysiology and arrhythmias
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion channel regulation and function

Share to Large-Conductance Calcium-Activated Potassium Channel alpha Subunits

Share to Muscle, Smooth, Vascular

Share to Polymorphism, Single Nucleotide

Share to Receptor Mechanisms and Signaling

Source

Identifiers

PMID: 20043229
DOI: 10.1007/s00424-009-0768-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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