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EGFR Mutations and Lung Cancer

24 Jan 2011

Abstract excerpt

Epidermal growth factor receptor (EGFR) is a transmembrane protein with cytoplasmic kinase activity that transduces important growth factor signaling from the extracellular milieu to the cell. Given that more than 60% of non-small cell lung carcinomas (NSCLCs) express EGFR, EGFR has become an important therapeutic target for the treatment of these tumors. Inhibitors that target the kinase domain of EGFR have been...

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PMID: 20887192
DOI: 10.1146/annurev-pathol-011110-130206

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