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Article

Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumor biology.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2005

Jänne Pasi A, Engelman Jeffrey A, Johnson Bruce E

Abstract excerpt

The epidermal growth factor receptor (EGFR) has emerged as an attractive therapeutic target for patients with non-small-cell lung cancer (NSCLC). However, despite its almost universal presence in NSCLC tumors, therapeutic inhibition of EGFR has resulted in significant tumor regressions in only 10% to 20% of patients. Several investigations over the last 12 months have uncovered somatic mutations in EGFR that...

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Identifiers

PMID: 15886310
DOI: 10.1200/JCO.2005.09.985

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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