Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study.

doi:10.1371/journal.pone.0228925

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Article

Clinical significance of EGFR mutation types in lung adenocarcinoma: A multi-centre Korean study.

PloS one - 1 Jan 2020

Yoon Hee-Young, Ryu Jeong-Seon, Sim Yun Su, Kim Dojin, Lee Sung Yong, Choi Juwhan, Park Sojung, Ryu Yon Ju, Lee Jin Hwa, Chang Jung Hyun

Abstract excerpt

Adenocarcinoma is the most common type of non-small cell lung cancer. Some causative genomic alterations in epidermal growth factor receptor (EGFR), including deletions in exon 19 (E19 dels) and a point mutation in E21, are known to have favourable prognoses due to sensitivity to tyrosine kinase inhibitors; however, the prognoses of other uncommon mutations are unclear. This study analysed the clinical...

Topics

Adenocarcinoma of Lung
Aged
Asian People
Carcinoma, Non-Small-Cell Lung
ErbB Receptors
Exons
Female
Humans
Lung Neoplasms
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Point Mutation

Prognosis

Republic of Korea

Retrospective Studies

Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 32053675
DOI: 10.1371/journal.pone.0228925
PMCID: PMC7018076

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