Article
Identification of a chloroquine importer in Plasmodium falciparum. Differences in import kinetics are genetically linked with the chloroquine-resistant phenotype.
The Journal of biological chemistry - 31 Jan 1997
Sanchez C P, Wünsch S, Lanzer M
Abstract excerpt
We demonstrate that uptake of the antimalarial drug chloroquine is temperature-dependent, saturable, and inhibitable in Plasmodium falciparum. These features are indicative of carrier-mediated transport and suggest that a P. falciparum-encoded protein facilitates chloroquine import. Although both...
Topics
- Amiloride
- Animals
- Binding, Competitive
- Biological Transport
- Chloroquine
- Crosses, Genetic
- Drug Resistance
- Erythrocytes
- Humans
- Kinetics
- Phenotype
- Plasmodium falciparum
- Sodium-Hydrogen Exchangers
- Temperature