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Article

Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.

Molecular and cellular biology - 1 Dec 2005

Shen Hong Ming, Ratnam Sarayu, Storb Ursula

Abstract excerpt

Activation-induced deaminase (AID) initiates immunoglobulin somatic hypermutation (SHM). Since in vitro AID was shown to deaminate cytosines on single-stranded DNA or the nontranscribed strand, it remained a puzzle how in vivo AID targets both DNA strands equally. Here we investigate the roles of transcription and DNA sequence in cytosine deamination. Strikingly different results are found with different...

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Identifiers

PMID: 16314506
DOI: 10.1128/MCB.25.24.10815-10821.2005
PMCID: PMC1316976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single-Stranded DNA Structure and Positional Context of the Target Cytidine Determine the Enzymatic Efficiency of AIDSemantic proximity Read ↗

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation.Semantic proximity Read ↗

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