Article
Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand.
Nature immunology - 1 May 2003
Ramiro Almudena R, Stavropoulos Pete, Jankovic Mila, Nussenzweig Michel C
Abstract excerpt
Somatic hypermutation and class switch recombination are DNA modification reactions that alter the genes encoding antibodies in B lymphocytes. Both of these distinct reactions require activation-induced deaminase (AID) and transcription. Here we show that in Escherichia coli, as in eukaryotic cells, the mutation frequency is directly proportional to the transcription of target genes. Transcription enhances...
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