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Article

The graded response to Sonic Hedgehog depends on cilia architecture.

Developmental cell - 1 May 2007

Caspary Tamara, Larkins Christine E, Anderson Kathryn V

Abstract excerpt

Several studies have linked cilia and Hedgehog signaling, but the precise roles of ciliary proteins in signal transduction remain enigmatic. Here we describe a mouse mutation, hennin (hnn), that causes coupled defects in cilia structure and Sonic hedgehog (Shh) signaling. The hnn mutant cilia are short with a specific defect in the structure of the ciliary axoneme, and the hnn neural tube shows a Shh-independent...

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Identifiers

PMID: 17488627
DOI: 10.1016/j.devcel.2007.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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