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Article

Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix.

The Journal of cell biology - 7 May 2007

Bass Mark D, Roach Kirsty A, Morgan Mark R, Mostafavi-Pour Zohreh, Schoen Tobias, Muramatsu Takashi, Mayer Ulrike, Ballestrem Christoph, Spatz Joachim P, Humphries Martin J

Abstract excerpt

Cell migration in wound healing and disease is critically dependent on integration with the extracellular matrix, but the receptors that couple matrix topography to migratory behavior remain obscure. Using nano-engineered fibronectin surfaces and cell-derived matrices, we identify syndecan-4 as a key signaling receptor determining directional migration. In wild-type fibroblasts, syndecan-4 mediates the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17485492
DOI: 10.1083/jcb.200610076
PMCID: PMC1885470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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