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Article

Distinct signaling mechanisms regulate migration in unconfined versus confined spaces.

The Journal of cell biology - 2 Sept 2013

Hung Wei-Chien, Chen Shih-Hsun, Paul Colin D, Stroka Kimberly M, Lo Ying-Chun, Yang Joy T, Konstantopoulos Konstantinos

Abstract excerpt

Using a microchannel assay, we demonstrate that cells adopt distinct signaling strategies to modulate cell migration in different physical microenvironments. We studied α4β1 integrin-mediated signaling, which regulates cell migration pertinent to embryonic development, leukocyte trafficking, and melanoma invasion. We show that α4β1 integrin promotes cell migration through both unconfined and confined spaces....

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Identifiers

PMID: 23979717
DOI: 10.1083/jcb.201302132
PMCID: PMC3760608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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