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Article

PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration.

The Journal of investigative dermatology - 1 Jun 2006

Fan Jianhua, Guan Shengxi, Cheng Chieh-Fang, Cho Michele, Fields Joshua W, Chen Mei, Denning Mitchell F, Woodley David T, Li Wei

Abstract excerpt

We have previously shown that the immobilized extracellular matrices (ECMs) initiate cell migration and soluble growth factors (GFs) further enhance ECM-initiated cell migration. GFs alone cannot initiate cell migration. To further investigate the specificity of the two signaling mechanisms, we focused on the protein kinase C (PKC) family genes in primary human dermal fibroblasts (DFs). We here show that...

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PMID: 16543902
DOI: 10.1038/sj.jid.5700149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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