Article
Alpha4beta1 and alpha5beta1 control cell migration on fibronectin by differentially regulating cell speed and motile cell phenotype.
Annals of biomedical engineering - 1 Jan 2000
Chon J H, Netzel R, Rock B M, Chaikof E L
Abstract excerpt
Computer-aided time lapse fluorescence videomicroscopy was used to study single cell migration behavior of human aortic endothelial cells on fibronectin coated substrates of varying protein surface density. The role of receptors alpha5beta1, alpha(v)beta3, and alpha4beta1 in mediating cell adhesi...
Topics
- Antibodies, Monoclonal
- Biomedical Engineering
- Cell Adhesion
- Cell Movement
- Cells, Cultured
- Endothelium, Vascular
- Extracellular Matrix
- Fibronectins
- Humans
- Integrin alpha4beta1
- Integrins
- Phenotype
- Receptors, Fibronectin
- Receptors, Lymphocyte Homing
- Surface Properties