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Article

Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin.

Journal of cell science - 1 Sept 2003

Russell Alan J, Fincher Edgar F, Millman Linda, Smith Robyn, Vela Veronica, Waterman Elizabeth A, Dey Clara N, Guide Shireen, Weaver Valerie M, Marinkovich M Peter

Abstract excerpt

Growth factor-induced cell migration and proliferation are essential for epithelial wound repair. Cell migration during wound repair also depends upon expression of laminin-5, a ligand for alpha 6 beta 4 integrin. We investigated the role of alpha 6 beta 4 integrin in laminin-5-dependent keratinocyte migration by re-expressing normal or attachment-defective beta 4 integrin in beta 4 integrin null keratinocytes....

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Identifiers

PMID: 12865436
DOI: 10.1242/jcs.00663

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin.PMID 12865436Read ↗

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