Functional CRISPR-Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity

Abstract excerpt

<title>Abstract</title> <p>Directional cell migration plays a central role in a wide range of physiological and pathological conditions, such as embryonic development or tumor metastasis. Steps involved in cell migration include cell polarization, formation of membrane protrusions at the cell front side and adhesion disassembly at the rear side, and a general cytoskeletal rearrangement. Overall it is a complex ph...

Topics

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• Cell Adhesion Molecules Research
• Cell Line, Tumor
• Cell Movement
• Oligonucleotide Array Sequence Analysis
• Phenotype
• RNA, Small Interfering
• Transfection
• Transgenes

Identifiers and source

Literature Corpus work

e0a6b3a3-2f8a-5145-a09b-5281300afe96

DOI

10.21203/rs.3.rs-4306480/v2