Article
Comparative assessment of the association information captured by SNP tagging.
Human heredity - 1 Jan 2007
Nothnagel Michael, Wollstein Andreas, Krawczak Michael
Abstract excerpt
Exploiting the association between single nucleotide polymorphisms (SNP) can potentially reduce the costs of association mapping of common disease genes. Different methods have been proposed for defining subsets of SNPs as proxies (or tagSNPs) for other SNPs, some of which rely upon a model of haplotype blocks. Other approaches only consider the pair-wise correlation between markers as a basis for selecting...
Topics
- Child
- Chromosomes, Human, Pair 19
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Techniques
- Humans
- Male
- Polymorphism, Single Nucleotide