Article
Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database.
Genetic epidemiology - 1 Feb 2006
Willer Cristen J, Scott Laura J, Bonnycastle Lori L, Jackson Anne U, Chines Peter, Pruim Randall, Bark Craig W, Tsai Ya-Yu, Pugh Elizabeth W, Doheny Kimberly F, Kinnunen Leena, Mohlke Karen L, Valle Timo T, Bergman Richard N, Tuomilehto Jaakko, Collins Francis S, Boehnke Michael
Abstract excerpt
The pattern and nature of linkage disequilibrium in the human genome is being studied and catalogued as part of the International HapMap Project [:2003 Nature 426:789-796]. A key goal of the HapMap Project is to enable identification of tag single nucleotide polymorphisms (SNPs) that capture a substantial portion of common human genetic variability while requiring only a small fraction of SNPs to be genotyped...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 14
- Finland
- Gene Frequency
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Models, Statistical
- Polymorphism, Single Nucleotide