Automatic identification and clustering of chromosome phenotypes in a genome wide RNAi screen by time-lapse imaging.

Abstract excerpt

High-throughput time-lapse microscopy is an excellent way of studying gene function by collecting time-resolved image data of the cellular responses to gene perturbations. With the increase in both data amount and complexity, computational methods capable of dealing with large image data sets are required. While image processing methods have been successfully applied to endpoint assays in the past, the analysis...

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