Article
A likelihood-based index of protein protein binding affinities with application to influenza HA escape from antibodies.
Molecular biology and evolution - 1 Aug 2007
Watabe Teruaki, Kishino Hirohisa, de Oliveira Martins Leonardo, Kitazoe Yasuhiro
Abstract excerpt
In many biological systems, proteins interact with other organic molecules to produce indispensable functions, in which molecular recognition phenomena are essential. Proteins have kept or gained their functions during molecular evolution. Their functions seem to be flexible, and a few amino acid substitutions sometimes cause drastic changes in function. In order to monitor and predict such drastic changes in the...
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