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Article

Maximum-Entropy Models of Sequenced Immune Repertoires Predict Antigen-Antibody Affinity.

PLoS computational biology - 1 Apr 2016

Asti Lorenzo, Uguzzoni Guido, Marcatili Paolo, Pagnani Andrea

Abstract excerpt

The immune system has developed a number of distinct complex mechanisms to shape and control the antibody repertoire. One of these mechanisms, the affinity maturation process, works in an evolutionary-like fashion: after binding to a foreign molecule, the antibody-producing B-cells exhibit a high-frequency mutation rate in the genome region that codes for the antibody active site. Eventually, cells that produce...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27074145
DOI: 10.1371/journal.pcbi.1004870
PMCID: PMC4830580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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