Article
Quantifying selection and diversity in viruses by entropy methods, with application to the haemagglutinin of H3N2 influenza.
Journal of the Royal Society, Interface - 7 Nov 2011
Pan Keyao, Deem Michael W
Abstract excerpt
Many viruses evolve rapidly. For example, haemagglutinin (HA) of the H3N2 influenza A virus evolves to escape antibody binding. This evolution of the H3N2 virus means that people who have previously been exposed to an influenza strain may be infected by a newly emerged virus. In this paper, we use Shannon entropy and relative entropy to measure the diversity and selection pressure by an antibody in each amino...
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