Article
An evolutionary trace method defines binding surfaces common to protein families.
Journal of molecular biology - 29 Mar 1996
Lichtarge O, Bourne H R, Cohen F E
Abstract excerpt
X-ray or NMR structures of proteins are often derived without their ligands, and even when the structure of a full complex is available, the area of contact that is functionally and energetically significant may be a specialized subset of the geometric interface deduced from the spatial proximity...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Conserved Sequence
- DNA-Binding Proteins
- Databases, Factual
- Evolution, Molecular
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation