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Article

The protein-protein interface evolution acts in a similar way to antibody affinity maturation.

The Journal of biological chemistry - 5 Feb 2010

Li Bohua, Zhao Lei, Wang Chong, Guo Huaizu, Wu Lan, Zhang Xunming, Qian Weizhu, Wang Hao, Guo Yajun

Abstract excerpt

Understanding the evolutionary mechanism that acts at the interfaces of protein-protein complexes is a fundamental issue with high interest for delineating the macromolecular complexes and networks responsible for regulation and complexity in biological systems. To investigate whether the evolution of protein-protein interface acts in a similar way as antibody affinity maturation, we incorporated evolutionary...

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Share to Antibodies, Monoclonal, Murine-Derived
Share to Antibody Affinity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, CD

Share to Crystallography, X-Ray

Share to CTLA-4 Antigen

Share to Interleukin-2 Receptor alpha Subunit

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Source

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Identifiers

PMID: 20007707
DOI: 10.1074/jbc.M109.076547
PMCID: PMC2823529

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