Article
Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals.
The EMBO journal - 6 Jun 2007
Danckwardt Sven, Kaufmann Isabelle, Gentzel Marc, Foerstner Konrad U, Gantzert Anne-Susan, Gehring Niels H, Neu-Yilik Gabriele, Bork Peer, Keller Walter, Wilm Matthias, Hentze Matthias W, Kulozik Andreas E
Abstract excerpt
The prothrombin (F2) 3' end formation signal is highly susceptible to thrombophilia-associated gain-of-function mutations. In its unusual architecture, the F2 3' UTR contains an upstream sequence element (USE) that compensates for weak activities of the non-canonical cleavage site and the downstream U-rich element. Here, we address the mechanism of USE function. We show that the F2 USE contains a highly conserved...
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