Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence.

The EMBO journal - 5 May 2010

Nunes Nuno Miguel, Li Wencheng, Tian Bin, Furger André

Abstract excerpt

We have analysed the sequences required for cleavage and polyadenylation in the intronless melanocortin 4 receptor (MC4R) pre-mRNA. Unlike other intronless genes, 3'end processing of the MC4R primary transcript is independent of any auxiliary sequence elements and only requires the core poly(A) sequences. Mutation of the AUUAAA hexamer had little effect on MC4R 3'end processing but small changes in the short DSE...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Flanking Region
Share to Adenosine
Share to Antigens, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Poly A

Share to Proto-Oncogene Proteins c-jun

Share to Receptor, Melanocortin, Type 4

Share to RNA Precursors

Share to Uridine

Source

Open in PubMed Open full text

Identifiers

PMID: 20339349
DOI: 10.1038/emboj.2010.42
PMCID: PMC2876958

Genes

DSE
JUNB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence.PMID 20339349Read ↗

A compendium of conserved cleavage and polyadenylation events in mammalian genes.Semantic proximity Read ↗

A comprehensive analysis of 3’ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogenous ribonucleoprotein C on cleavage and polyadenylationSemantic proximity Read ↗

Patterns of variant polyadenylation signal usage in human genes.Semantic proximity Read ↗

Implications of Poly(A) Tail Processing in Repeat Expansion DiseasesSemantic proximity Read ↗

Single nucleotide polymorphisms can create alternative polyadenylation signals and affect gene expression through loss of microRNA-regulation.Semantic proximity Read ↗

scaRNA1 Levels Alter Pseudouridylation in Spliceosomal RNA U2 Affecting Alternative mRNA Splicing and Embryonic DevelopmentSemantic proximity Read ↗

Are U4 small nuclear ribonucleoproteins involved in polyadenylation?Semantic proximity Read ↗

Upstream Elements Present in the 3′-Untranslated Region of Collagen Genes Influence the Processing Efficiency of Overlapping Polyadenylation SignalsSemantic proximity Read ↗

Sequence variations affecting AU-rich element function and disease.Semantic proximity Read ↗

To polyadenylate or to deadenylateSemantic proximity Read ↗

The RS Domain of Human CFIm68 Plays a Key Role in Selection Between Alternative Sites of Pre-mRNA Cleavage and PolyadenylationSemantic proximity Read ↗

Alternative polyadenylation mediated by CPSF5 regulates pro-inflammatory gene expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.