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Article

The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms.

Genes & development - 15 Aug 1998

Moreira A, Takagaki Y, Brackenridge S, Wollerton M, Manley J L, Proudfoot N J

Abstract excerpt

The poly(A) signal of the C2 complement gene is unusual in that it possesses an upstream sequence element (USE) required for full activity in vivo. We describe here in vitro experiments demonstrating that this USE enhances both the cleavage and poly(A) addition reactions. We also show that the C2 USE can be cross-linked efficiently to a 55-kD protein that we identify as the polypyrimidine tract-binding protein...

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Identifiers

PMID: 9716405
DOI: 10.1101/gad.12.16.2522
PMCID: PMC317083

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Source receipt: pubmed, retrieved 7 Sept 2026.

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