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Article

Upstream sequence elements enhance poly(A) site efficiency of the C2 complement gene and are phylogenetically conserved.

The EMBO journal - 1 Aug 1995

Moreira A, Wollerton M, Monks J, Proudfoot N J

Abstract excerpt

Poly(A) signals of mammalian pre-mRNA have been defined as an AAUAAA sequence 10-30 nt upstream of the cleavage/poly(A) site followed by a GU/U-rich element immediately downstream. However, a number of viral poly(A) signals have been shown to possess additional signals upstream of AAUAAA that inc...

Topics

Animals
Base Sequence
Cats
Cattle
Complement C2
Complement Factor B
Conserved Sequence
Genes
HeLa Cells
Humans
Mice
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poly A

Rabbits

Regulatory Sequences, Nucleic Acid

Sequence Analysis, DNA

Terminator Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7641699
DOI: 10.1002/j.1460-2075.1995.tb00050.x
PMCID: PMC394455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7641699-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Upstream sequence elements enhance poly(A) site efficiency of the C2 complement gene and are phylogenetically conserved.PMID 7641699Read ↗

The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms.Semantic proximity Read ↗

Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals.Semantic proximity Read ↗

Upstream Elements Present in the 3′-Untranslated Region of Collagen Genes Influence the Processing Efficiency of Overlapping Polyadenylation SignalsSemantic proximity Read ↗

A functional human Poly(A) site requires only a potent DSE and an A-rich upstream sequence.Semantic proximity Read ↗

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Upstream and downstream cis-acting elements for cleavage at the L4 polyadenylation site of adenovirus-2.Semantic proximity Read ↗

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The relationship between the prothrombin upstream sequence element and the G20210A polymorphism: the influence of a competitive environment for mRNA 3'-end formation.Semantic proximity Read ↗

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