Article
The role of U2AF35 and U2AF65 in enhancer-dependent splicing.
RNA (New York, N.Y.) - 1 Jun 2001
Graveley B R, Hertel K J, Maniatis T
Abstract excerpt
Splicing enhancers are RNA sequence elements that promote the splicing of nearby introns. The mechanism by which these elements act is still unclear. Some experiments support a model in which serine-arginine (SR)-rich proteins function as splicing activators by binding to enhancers and recruiting the splicing factor U2AF to an adjacent weak 3' splice site. In this model, recruitment requires interactions between...
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