Functional polymorphisms of the Lss and Fdft1 genes in laboratory rats.

doi:10.1538/expanim.56.93

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Article

Functional polymorphisms of the Lss and Fdft1 genes in laboratory rats.

Experimental animals - 1 Apr 2007

Mori Masayuki, Sawashita Jinko, Higuchi Keiichi

Abstract excerpt

We previously identified mutant alleles of the lanosterol synthase (Lss) and farnesyl diphosphate farnesyl transferase 1 (Fdft1) genes, which function in the cholesterol biosynthesis pathway, as determinants for hereditary cataracts in the SCR rat strain. Lss(S) and Fdft1(S) were established as hypomorphic alleles with missense nucleotide substitutions, while Lss(l) is a null allele with nucleotide...

Topics

Animals
Base Sequence
DNA Mutational Analysis
Farnesyl-Diphosphate Farnesyltransferase
Genetic Testing
Genome
Genotype
Intramolecular Transferases
Liver
Molecular Sequence Data
Polymorphism, Single Nucleotide
Rats
Rats, Inbred SHR
Rats, Zucker

Source

Open in PubMed

Identifiers

PMID: 17460354
DOI: 10.1538/expanim.56.93

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