Article
A genetic and correlation analysis of liver cholesterol concentration in rat recombinant inbred strains fed a high cholesterol diet.
Biochemical and biophysical research communications - 8 May 1998
Bottger A, Lankhorst E, van Lith H A, van Zutphen L F, Zídek V, Musilová A, Simáková M, Poledne R, Bílá V, Køen V, Pravenec M
Abstract excerpt
Liver cholesterol concentration in rats fed a high cholesterol diet, is under genetic control which is supported by significant differences observed among inbred strains. For instance, the Brown Norway (BN-Lx/Cub) rat developed a twofold higher liver cholesterol concentration than the spontaneous...
Topics
- Animals
- Carrier Proteins
- Cholesterol
- Cholesterol, Dietary
- Chromosome Mapping
- Diet, Atherogenic
- Female
- Genetic Linkage
- Lipoproteins
- Liver
- Male
- Organic Anion Transporters, Sodium-Dependent
- Phenotype
- Quantitative Trait, Heritable