Article
A genetic and correlation analysis of liver cholesterol concentration in rat recombinant inbred strains fed a high cholesterol diet.
Biochemical and biophysical research communications - 8 May 1998
Bottger A, Lankhorst E, van Lith H A, van Zutphen L F, Zídek V, Musilová A, Simáková M, Poledne R, Bílá V, Køen V, Pravenec M
Abstract excerpt
Liver cholesterol concentration in rats fed a high cholesterol diet, is under genetic control which is supported by significant differences observed among inbred strains. For instance, the Brown Norway (BN-Lx/Cub) rat developed a twofold higher liver cholesterol concentration than the spontaneously hypertensive rat (SHR/Ola). In the current study, we used 30 recombinant inbred (RI) strains, derived from BN-Lx and...
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