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Article

Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat.

The Journal of clinical investigation - 1 Feb 2006

Mori Masayuki, Li Guixin, Abe Ikuro, Nakayama Jun, Guo Zhanjun, Sawashita Jinko, Ugawa Tohru, Nishizono Shoko, Serikawa Tadao, Higuchi Keiichi, Shumiya Seigo

Abstract excerpt

The Shumiya cataract rat (SCR) is a hereditary cataractous strain. It is thought that the continuous occurrence of poorly differentiated epithelial cells at the bow area of the lens forms the pathophysiological basis for cataract formation in SCRs. In this study, we attempted to identify the genes associated with cataract formation in SCRs by positional cloning. Genetic linkage analysis revealed the presence of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16440058
DOI: 10.1172/JCI20797
PMCID: PMC1350995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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