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Article

Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates.

BMC genomics - 29 Nov 2005

Smits Bart M G, Guryev Victor, Zeegers Dimphy, Wedekind Dirk, Hedrich Hans J, Cuppen Edwin

Abstract excerpt

BACKGROUND: The laboratory rat (Rattus norvegicus) is an important model for studying many aspects of human health and disease. Detailed knowledge on genetic variation between strains is important from a biomedical, particularly pharmacogenetic point of view and useful for marker selection for genetic cloning and association studies. RESULTS: We show that Single Nucleotide Polymorphisms (SNPs) in commonly used...

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PMID: 16316463
DOI: 10.1186/1471-2164-6-170
PMCID: PMC1318490

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