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Article

Genome variation and conserved regulation identify genomic regions responsible for strain specific phenotypes in rat.

BMC genomics - 22 Dec 2017

Martín-Gálvez David, Dunoyer de Segonzac Denis, Ma Man Chun John, Kwitek Anne E, Thybert David, Flicek Paul

Abstract excerpt

BACKGROUND: The genomes of laboratory rat strains are characterised by a mosaic haplotype structure caused by their unique breeding history. These mosaic haplotypes have been recently mapped by extensive sequencing of key strains. Comparison of genomic variation between two closely related rat strains with different phenotypes has been proposed as an effective strategy for the discovery of candidate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29272997
DOI: 10.1186/s12864-017-4351-9
PMCID: PMC5741965

Genes

FOXA1

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