Article
Quantitative trait locus mapping of acute functional tolerance in the LXS recombinant inbred strains.
Alcoholism, clinical and experimental research - 1 Apr 2015
Bennett Beth, Larson Colin, Richmond Phillip A, Odell Aaron T, Saba Laura M, Tabakoff Boris, Dowell Robin, Radcliffe Richard A
Abstract excerpt
BACKGROUND: We previously reported that acute functional tolerance (AFT) to the hypnotic effects of alcohol was significantly correlated with drinking in the dark (DID) in the LXS recombinant inbred panel, but only in mice that had been pretreated with alcohol. Here, we have conducted quantitative trait locus (QTL) mapping for AFT. DNA sequencing of the progenitor ILS and ISS strains and microarray analyses were...
Topics
- Alcohol Drinking
- Animals
- Animals, Inbred Strains
- Brain
- Chromosome Mapping
- Drug Tolerance
- Ethanol
- Gene Expression Profiling
- Genetic Association Studies
- Genotype
- Male
- Mice
- Quantitative Trait Loci