Functional polymorphisms in inbred rat strains and their allele frequencies in commercially available outbred stocks.

doi:10.1152/physiolgenomics.00222.2007

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Article

Functional polymorphisms in inbred rat strains and their allele frequencies in commercially available outbred stocks.

Physiological genomics - 22 Apr 2008

Kuramoto Takashi, Nakanishi Satoshi, Serikawa Tadao

Abstract excerpt

Polymorphisms that have been proven to influence gene functions are called functional polymorphisms. It is significant to know the distribution of functional polymorphisms in the rat, widely used in animal models for human diseases. In this study, we assessed 16 functional polymorphisms consisting of 3 coat color and 13 disease-associated genes in 136 rat strains, as a part of the genetic profiling program of the...

Topics

Animals
Animals, Outbred Strains
Color
Disease
Gene Frequency
Genotype
Mutation
Polymorphism, Genetic
Rats
Rats, Inbred Strains

Source

Open in PubMed

Identifiers

PMID: 18212005
DOI: 10.1152/physiolgenomics.00222.2007

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