Article
Quantitative trait loci influencing blood and liver cholesterol concentration in rats.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2002
Bonné Anita C M, den Bieman Maria G, Gillissen Gert F, Lankhorst Aegidius, Kenyon Christopher J, van Zutphen Bert F M, van Lith Hein A
Abstract excerpt
OBJECTIVE: The LEW/OlaHsd and BC/CpbU rat inbred strains differ markedly in blood and hepatic cholesterol levels before and after a cholesterol-rich diet. To define loci controlling these traits and related phenotypes, an F2 population derived from these strains was genetically analyzed. METHODS AND RESULTS: For each of the 192 F2 animals, phenotypes were determined, and genomic DNA was screened for polymorphic...
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