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Article

Insulin increases the expression of contractile phenotypic markers in airway smooth muscle.

American journal of physiology. Cell physiology - 1 Jul 2007

Schaafsma Dedmer, McNeill Karol D, Stelmack Gerald L, Gosens Reinoud, Baarsma Hoeke A, Dekkers Bart G J, Frohwerk Erin, Penninks Jelte-Maarten, Sharma Pawan, Ens Karen M, Nelemans S Adriaan, Zaagsma Johan, Halayko Andrew J, Meurs Herman

Abstract excerpt

We have previously demonstrated that long-term exposure of bovine tracheal smooth muscle (BTSM) strips to insulin induces a functional hypercontractile phenotype. To elucidate molecular mechanisms by which insulin might induce maturation of contractile phenotype airway smooth muscle (ASM) cells, we investigated effects of insulin stimulation in serum-free primary BTSM cell cultures on protein accumulation of...

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Identifiers

PMID: 17459944
DOI: 10.1152/ajpcell.00502.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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