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Article

Phophatidylinositol-3 kinase/mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation.

American journal of respiratory cell and molecular biology - 1 Sept 2004

Halayko Andrew J, Kartha Sreedharan, Stelmack Gerald L, McConville John, Tam John, Camoretti-Mercado Blanca, Forsythe Sean M, Hershenson Marc B, Solway Julian

Abstract excerpt

Increased airway smooth muscle in airway remodeling results from myocyte proliferation and hypertrophy. Skeletal and vascular smooth muscle hypertrophy is induced by phosphatidylinositide-3 kinase (PI(3) kinase) via mammalian target of rapamycin (mTOR) and p70S6 kinase (p70S6K). We tested the hypothesis that this pathway regulates contractile protein accumulation in cultured canine airway myocytes acquiring an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ribosomal Protein S6 Kinases, 70-kDa

Source

Identifiers

PMID: 15105162
DOI: 10.1165/rcmb.2003-0272OC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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