Insulin-induced laminin expression promotes a hypercontractile airway smooth muscle phenotype.

Abstract excerpt

Airway smooth muscle (ASM) plays a key role in the development of airway hyperresponsiveness and remodeling in asthma, which may involve maturation of ASM cells to a hypercontractile phenotype. In vitro studies have indicated that long-term exposure of bovine tracheal smooth muscle (BTSM) to insulin induces a functional hypercontractile, hypoproliferative phenotype. Similarly, the extracellular matrix protein...

Topics

Join the communities discussing this publication.

• Administration, Inhalation
• Chromones
• Isometric Contraction
• Methacholine Chloride
• Morpholines