Article
Phenotype modulation of airway smooth muscle in asthma.
Pulmonary pharmacology & therapeutics - 1 Feb 2013
Wright David B, Trian Thomas, Siddiqui Sana, Pascoe Chris D, Johnson Jill R, Dekkers Bart G J, Dakshinamurti Shyamala, Bagchi Rushita, Burgess Janette K, Kanabar Varsha, Ojo Oluwaseun O
Abstract excerpt
The biological responses of airway smooth muscle (ASM) are diverse, in part due to ASM phenotype plasticity. ASM phenotype plasticity refers to the ability of ASM cells to change the degree of a variety of functions, including contractility, proliferation, migration and secretion of inflammatory mediators. This plasticity occurs due to intrinsic or acquired abnormalities in ASM cells, and these abnormalities or...
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